Our lab focuses on developing design principles for synthetic and systems biology by taking mathematical, computational, and experimental approaches.
One of the focus areas is stochasticity (noisy dynamics) and reliability in synthetically designed gene regulatory networks. We aim to answer the following questions:
- How can we design reliable biological networks under significant mutation pressure?
- How can we improve the designed function of engineered cells by exploiting intrinsic randomness (caused from random biological reactions)?
- Can we replace metabolically costly probes such as fluorescent proteins to RNA aptamer probes?
- If this is possible, how can we improve the intensity of the RNA aptamer probes?
- Can we use the RNA aptamer probes to track single RNA molecules in live cells? Can RNA molecules be even color coded?
These research — questions 1,2, and 3 — is currently supported by our new NSF award (PI: Kyung Kim, 2016-2018): Enhancing Robustness of Gene Regulatory Networks.
Thank you for your interest!
Kyung Hyuk Kim
University of Washington, Department of Bioengineering, William H. Foege Building, 3720 15th Ave NE, Seattle, WA 98195-5061